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The artwork features an Ouroboros (a snake that eats its own tail), stylized as a Lion (which represents House Lannister) and a Direwolf (the crest of House Stark). This symbolizes the cyclic Nature of the Universe: creation out of destruction, Life out of Death. The ouroboros eats its own tail to sustain its life, in an eternal cycle of renewal. The Starks and the Lannisters continue to fight until they destroy each other.
Cersei Lannister during the final confrontation with Eddard: "When you play the game of thrones, you win or you die. There is no middle ground."